ellagic acid improves hyperalgesia and cognitive deficiency in 6-hydroxidopamine induced rat model of parkinson’s disease
Authors
abstract
objective(s):parkinson's disease (pd) is known for motor impairments. but often, there are non-motor symptoms such as cognitive deficiency and pain misperception, owing to possible role of nigrostriatal pathway. antioxidants have protective effect on free radical-induced neuronal damage in pd. to further address, we examined the effects of ellagic acid (ea) in a rat model of pd induced by 6-hydroxidopamine (6-ohda). materials and methods: right medial forebrain bundle (mfb) was lesioned by injecting 6-ohda (16 µg/2 µl), in pd–animals.sham operated animals received vehicle instead of 6-ohda. pd was approved by apomorphine-induced contralateral rotation. ea (50 mg/kg/2 ml, po, for 10 days) was administered to pd-ea group. some pd-animals received pramipexole (ppx; 2 mg/kg/2 ml, po) as a positive control group. analgesia was measured by tail-flick and hot-plate tests. passive avoidance task was measured by shuttle box apparatus to record the initial and step-through latency. spatial cognition task was evaluated by morris water maze test, measuring the escape latency time, path length, swimming speed and time spent in target quadrant. results: mfb-lesioned rats showed hyperalgesic responses to the stimulus in tail-flick and hot-plate tests. also they showed memory and learning deficit in cognitive tests. these effects reversed by ea treatment. conclusion: 6-ohda can induce oxidative stress and can disrupt the neural mechanisms underlying proper integration of painful stimuli and cognitive processes in mfb-lesioned rats. consequently, nigrostriatal pathway can play possible role in nociception and cognition. ea, a natural antioxidant, has neuroprotective effect on this pathway and can ameliorate this defect and be considered in pd management.
similar resources
Ellagic acid improves hyperalgesia and cognitive deficiency in 6-hydroxidopamine induced rat model of Parkinson’s disease
Objective(s):Parkinson's disease (PD) is known for motor impairments. But often, there are non-motor symptoms such as cognitive deficiency and pain misperception, owing to possible role of nigrostriatal pathway. Antioxidants have protective effect on free radical-induced neuronal damage in PD. To further address, we examined the effects of ellagic acid (EA) in a rat model of PD induced by 6-hyd...
full textEllagic acid improves hyperalgesia and cognitive deficiency in 6-hydroxidopamine induced rat model of Parkinson’s disease
OBJECTIVES Parkinson's disease (PD) is known for motor impairments. But often, there are non-motor symptoms such as cognitive deficiency and pain misperception, owing to possible role of nigrostriatal pathway. Antioxidants have protective effect on free radical-induced neuronal damage in PD. To further address, we examined the effects of ellagic acid (EA) in a rat model of PD induced by 6-hydro...
full textEllagic Acid Protects the Brain Against 6-Hydroxydopamine Induced Neuroinflammation in a Rat Model of Parkinson’s Disease
Introduction: Neuroinflammation may play as an important risk factor in progressive degeneration of dopaminergic cells. Antioxidants have protective effects against free radicalsinduced neural damage in Parkinson’s disease (PD). In the present study, we examined the effects of ellagic acid (EA) on locomotion and neuroinflammatory biomarkers in a rat model of PD induced by 6-hydroxidopamin...
full textellagic acid protects the brain against 6-hydroxydopamine induced neuroinflammation in a rat model of parkinson’s disease
introduction: neuroinflammation may play as an important risk factor in progressive degeneration of dopaminergic cells. antioxidants have protective effects against free radicalsinduced neural damage in parkinson’s disease (pd). in the present study, we examined the effects of ellagic acid (ea) on locomotion and neuroinflammatory biomarkers in a rat model of pd induced by 6-hydroxidopamine (6-o...
full textSalvianolic Acid Improves Status Epilepticus and Learning and Memory Deficiency in Rat Model of Temporal Lobe Epilepsy
Background and Objective: Epilepsy is a long-lasting central nervous system disorder that is accompany with spontaneous seizures and insufficiency in learning and memory. Now drug treatment is the most common therapy but some patients do not research to suitable control of their seizures with current drugs. Hence, new treatment is needed to help those patients that are unaffected to existing dr...
full textEllagic acid improved arrhythmias induced by CaCL2 in the rat stress model
Objective: In ventricular arrhythmias, due to their free radical scavenging action, antioxidant agents are usually used in the treatment of cardiovascular disease. Since stress is considered as risk factor for increased mortality by causing malignant arrhythmias, the study was designed to evaluate the cardioprotective effects of ellagic acid (EA) on CaCl2-induced arrhythmias in rat stress model...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of basic medical sciencesجلد ۱۸، شماره ۱، صفحات ۳۸-۴۶
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023